Synthesis of gamma-halogenated ketones via the Ce(IV)-mediated oxidative coupling of cyclobutanols and inorganic halides.
نویسندگان
چکیده
A straightforward method for the synthesis of gamma-halo-substituted ketones formed via the CAN-initiated oxidative addition of halides to 1-substituted cyclobutanols has been developed. This method has short reaction times, and provides access to a range of bromo and iodo gamma-substituted ketones in good to excellent yields.
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ورودعنوان ژورنال:
- Tetrahedron letters
دوره 50 12 شماره
صفحات -
تاریخ انتشار 2009